Brisbane captain Darius Boyd looks set to return to fullback while winger Jordan Kahu appears on the outer as coach Wayne Bennett searches for consistency from his hot and cold NRL side.
The reshuffle will see teenager Gehamat Shibasaki land a home debut against North Queensland on Thursday, with the 19-year-old expected to be unleashed in the centres after being on the cusp of selection all season.
Boyd's shift to fullback would push Jamayne Isaako back to the wing as the Broncos chase a win to keep them in the hunt for a top-four finish.
They will be without Josh McGuire, though, who will take an early guilty plea and miss a game after being charged for pulling the hair of Canterbury's Adam Elliott in Thursday's loss.
Kahu was benched midway through that clash and trained with the reserves at Red Hill on Monday.
Isaako is viewed as the club's long-term fullback but said he didn't see a return to the wing as an insult.
"It's been good to get back there and get a good feel for playing fullback at the top level and learning off Darbs (Boyd)," he said.
"This allows me to go back to the wing and watch him do his thing in big games like this."
The Broncos' disappointing loss to the Bulldogs last Thursday followed impressive back-to-back wins over Penrith and Cronulla.
They sit seventh with four regular-season rounds remaining.
Acknowledging their up and down form, Isaako conceded his teammates had been guilty of panicking when things turned sour this season.
"When we go out there and things don't go our way a lot of players panic and, being so young, the boys look towards our older playing group to step up," he said.
"That's where as a team we need to buy in and work together."
Kahu overcame two knee reconstructions before making his NRL debut and returned from a badly broken jaw earlier this year to notch 91 NRL games and three Tests for New Zealand.
The 27-year-old is contracted to the Broncos until 2020 but now finds himself in a log-jam for spots given Kotoni Staggs' emergence as an option in the centres this season.
Staggs, who can also play in the back row, has impressed in stints off the bench this season but under NRL rules is unable to start for the side given he is not one of the club's top-30 contracted players.