Will Chambers is a shock inclusion to face former club Melbourne after being called into Cronulla's side for Friday night's crunch clash with the Storm.
Chambers has come in for the dropped Josh Dugan, after just one game in reserve grade following the former representative star's return from rugby union.
Captain Wade Graham is also back for Cronulla in the second row after missing two games through concussion, while George Jennings joins Ryan Papenhuyzen in Melbourne's casualty ward.
Chambers and Graham headline a list of high-profile returns for round seven.
Ryan Matterson is finally set to make his comeback for Parramatta from his round-two concussion, after getting through a NSW Cup match unscathed last week.
Ben Hunt has recovered from a fractured leg to feature in St George Illawarra's halves, allowing Jack Bird to go back to the centres after last week's failed shift.
Jason Taumalolo is also back for North Queensland against the Warriors on Sunday, after two straight hand fractures.
The Cowboys captain has not been available since his effort was criticised by coach Todd Payten after round one.
"He's got to get through Thursday's contact session, if he gets through that without breaking any more bones, he'll be right to play," Payten said.
"He's turned up to training every day. I know he's been a little bit disconnected from the main group.
"But he's got his work done.
"I spoke to him this morning and he's keen to play."
The Warriors have sprung a surprise for the clash, with rookie Reece Walsh moved to five-eighth and superstar Roger Tuivasa-Sheck returning to fullback.
Elsewhere Josh Papalii won't face South Sydney on Thursday night, with Canberra claiming the Queensland State of Origin prop has been "rested".
After three straight losses, captain Jarrod Croker will also miss with a shoulder injury.
Brisbane have dropped Tom Dearden and Brodie Croft, with Anthony Milford and Tyson Gamble returning to their halves from reserve grade.
St George Illawarra will also debut 20-year-old winger Max Feagai against Wests Tigers with Mikaele Ravalawa and Jordan Pereira both suspended.
Meanwhile Tigers coach Michael Maguire opted against mass changes, dropping only Michael Chee-Kam and Zane Musgrove from the side that was thumped by Manly.
And James Tedesco remains a chance to play for the Sydney Roosters against Newcastle, with the superstar named at fullback despite his head knock on Anzac Day.