The Canadian Grand Prix, scheduled for June 13 at the Circuit Gilles Villeneuve in Montreal, has been cancelled for the second year in a row because of the COVID-19 pandemic, CBC Radio has reported.
Thursday's report said Montreal public health authorities concluded that even if run behind closed doors without spectators the current health risks were too high to stage the event - but Formula One said discussions were still ongoing.
The news comes amid a spread of new COVID-19 variants, with Canada battling to contain a third wave of the virus, .
F1 officials, according to the CBC, wanted to bypass the mandatory 14-day quarantine for the hundreds of staff, crew members and drivers and rely on private medical staff and have the entire operation run in a bubble.
The race is scheduled to follow on immediately from Azerbaijan, whose grand prix is scheduled for June 6 in Baku and is due to go ahead after also being cancelled last year.
"We are continuing our discussions with the promoter in Canada and have no further comment," an F1 spokesperson told Reuters.
The Autosport website quoted a spokesperson for the Canadian promoter as saying the radio report referred to "a document of recommendations from public health.
Canada, with some of the world's toughest travel rules, obliges its citizens and residents arriving from abroad to self-isolate for 14 days.
One of Canada's biggest sporting events, it would mark the second consecutive year the grand prix has been removed from the F1 schedule due to the spread of COVID-19.
Media reports have suggested Turkey is on stand-by to be slotted in as Canada's replacement.
The Istanbul circuit is logistically convenient for freight coming from Baku and was brought in last year also at short notice to bolster a calendar ravaged by the pandemic.