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The Western Bulldogs have been boosted by the return of Aaron Naughton and Josh Dunkley for their AFL clash with Gold Coast, while Port Adelaide have been hit hard by injuries as they prepare to take on St Kilda.
Dunkley returns for his first AFL game since round six after recovering from a shoulder injury, while Naughton (concussion) slots straight back into the side as the Bulldogs attempt to bounce back from last week's shock loss to Sydney.
Defender Hayden Crozier and winger Roarke Smith also come back into the side, and last week's unused medical sub Lachie McNeil has been elevated into the starting 22.
Midfielder Tom Liberatore has been rested, while Lewis Young, Mitch Wallis, Anthony Scott, and Mitch Hannan were dropped.
The Suns lost Sam Day (foot), Hugh Greenwood (knee), and Oleg Markov (calf) to injury.
Port Adelaide were dealt a triple blow when Zak Butters (knee), Steven Motlop (ankle), and Cozee Rozee (knee soreness) were all ruled out of Saturday's clash with St Kilda.
The Power recalled Riley Bonner, Boyd Woodcock, and Peter Ladhams, while the rejuvenated Saints go in unchanged as they attempt to win four in a row.
Richmond have been boosted by the return of triple premiership-winning duo Kane Lambert and Toby Nankervis for Friday night's match against Brisbane, with former Saint Matthew Parker to make his Tigers debut.
The Lions lost key position duo Eric Hipwood (knee) and Marcus Adams (foot).
Ryan Lester is back from a hamstring injury, and youngsters Tom Fullarton and Jaxon Prior won recalls.
Hawthorn's task of toppling Melbourne on Saturday was made harder after injuries ruled out Jack Scrimshaw (concussion), Changkuoth Jiath (knee), and Jonathon Ceglar (hip).
Tim O'Brien, Mitch Lewis, and Ned Reeves were recalled.
North Melbourne have decided to rest star midfielder Ben Cunnington for Sunday's encounter with Essendon.
The Bombers lost midfielder Kyle Langford (hamstring) but regained skipper Dyson Heppell from a thumb injury.
Collingwood big man Mason Cox was named on the extended interchange bench and is a chance to play in Sunday's clash with Carlton.
Blues defender Liam Jones will return from a back injury, while Zac Fisher could also come in after being named in the extended side.
Adelaide have been boosted by the return of forwards Taylor Walker and Tom Lynch for Sunday's meeting with West Coast.
Walker missed one match with a neck injury, while Lynch will be playing his first AFL game since undergoing toe surgery in May.
The Eagles lost Brendon Ah Chee (fractured hand) and defender Tom Barrass (hamstring), but will hand a debut to mid-season rookie draft selection Connor West,.
Key defender Harry Edwards replaces Barrass, while premiership tagger Mark Hutchings was named on an extended bench.
GWS will be without ruckman Shane Mumford (back), midfielder Lachie Whitfield (concussion), and forward Bobby Hill (managed) for their derby against Sydney on Sunday.
Giants captain Stephen Coniglio returns after overcoming a syndesmosis injury, while Matt Flynn has also been confirmed for a recall.