Simmons out in NBA loss, Griffin lands 50

Blake Griffin led Detroit to victory over a Ben Simmons-less 76ers, with a record 50-point haul

Ben Simmons has rested his troublesome back as Blake Griffin's career-high 50 points propelled the Detroit Pistons to a dramatic 133-132 NBA overtime victory over the Philadelphia 76ers.

Simmons watched on as Griffin ran rampant for the hosts, landing the decisive free throw after being fouled when driving to the hoop and making a lay-up with 1.8 seconds remaining.

Philadelphia coach Brett Brown revealed Australian star Simmons is no certainty for the Sixers' next assignment at the Milwaukee Bucks on Wednesday as he manages back tightness.

The issue flared up in the warm-up of Saturday's game against the Orlando Magic with the reigning rookie of the year being pulled in the first quarter.

"He didn't feel as comfortable as we would've wanted," Brown said before the decision was made to leave Simmons out of Tuesday's loss in Detroit.

"It's just one of those things that with a back-to-back game and giving him the best chance we could give him to possibly play (Wednesday).

"We felt like it was wise to sit him tonight."

JJ Redick's four-point play with 5.6 seconds left in overtime edged the Sixers ahead before Griffin's heroics at Little Caesars Arena.

Sixers All-Star centre Joel Embiid, who had 33 points and 11 rebounds, missed a potential game-winner at the buzzer.

Griffin, who topped his previous best haul of 47 points, made 20 of 35 field-goal attempts but was just five of 11 from the free-throw line. He added 14 rebounds and six assists.

The Pistons are now 3-0 for the first time since 2015/16, the last time they made the playoffs.

Elsewhere, Nikola Jokic had 14 points and 12 rebounds in just 23 minutes and Jamal Murray scored 19 to lead the Denver Nuggets to a 126-112 win over the Sacramento Kings.

Denver (4-0) are off to their best start since they won first in a row in the 2009/10 season.

Anthony Davis had 34 points and 13 rebounds as the host New Orleans Pelicans continued their early-season roll with a 116-109 victory over the Los Angeles Clippers.

The Pelicans scored 24 fewer points than they had averaged in winning their first two games but still cruised to victory and their first 3-0 start to a campaign since 2010/11.