Leipzig's new coach Marco Rose has overseen a 3-0 rout of Borussia Dortmund, the club which fired him at the end of last season, while Bayern Munich were held 2-2 by Stuttgart in their third straight Bundesliga draw.
Serhou Guirassy scored an injury-time penalty for Stuttgart in another blow for Bayern on Saturday ahead of their Champions League group-stage game against Barcelona on Tuesday.
Bayern had also drawn their previous league games against Union Berlin and Borussia Monchengladbach.
Rose takes Leipzig to Real Madrid on Wednesday in the Champions League after claiming a refreshing victory over Dortmund on his Leipzig debut.
Rose, appointed by Leipzig on Thursday to take over from the fired Domenico Tedesco, steered Leipzig to what was just their second win in six Bundesliga games.
Will Orban got Rose's team off to a great start with a header after a corner in the sixth and Leipzig maintained the intensity until Dominik Szoboszlai made it 2-0 with a brilliant strike from distance before the break.
Dortmund improved after the interval but Amadou Haidara sealed Leipzig's win in the 84th.
Bayern were unable to profit much from Dortmund's slip, though it looked fine when Mathys Tel opened the scoring in the 36th. Alphonso Davies cut the ball back for the French teenager's first Bundesliga goal.
Stuttgart's Guirassy had an equaliser ruled out after the break through VAR for a foul by Chris Fuhrich in the build-up.
TV replays showed a slight tug on Joshua Kimmich's shirt before Fuhrich set up his teammate.
But Fuhrich atoned by scoring in the 57th when Konstantinos Mavropanos intercepted Davies' poor pass to play him through.
Then Jamal Musiala showed his skill with a sleight of foot to elude Atakan Karazor before sending the ball inside the left post on the hour-mark. It was the 19-year-old's fourth goal in five league appearances.
VAR played a role again when Matthijs de Ligt was penalised in injury time. Guirassy stole a point for Stuttgart with the spot kick.
Elsewhere, Bayer Leverkusen came back to draw at Hertha Berlin 2-2, Hoffenheim enjoyed a 4-1 win over 10-man Mainz, and Niko Kovac's Wolfsburg team earned a 1-0 win at his former club Eintracht Frankfurt.
Schalke defeated winless Bochum 3-1 in their derby later on Saturday, leaving the visitors with no points after six games and coach Thomas Reis under increasing pressure.
It was promoted Schalke's first win of the season.