Winger Chris Ashton and lock Courtney Lawes will start for England in their Six Nations clash with France at Twickenham on Sunday in the only two changes to the team that so impressively beat holders Ireland 32-20 in last week's opener.
Ashton, who came off the bench late in the Dublin game, will be making his first Six Nations start for six years, and replaces Jack Nowell, who drops to the bench.
Lawes, also impressive as a replacement last week, comes in for the injured Maro Itoje, with Joe Launchbury added to the replacements.
Itoje was expected to be missing until the final rounds of the tournament with a knee injury but coach Eddie Jones has revealed he might be back sooner than expected from his grade two medial ligament tear.
"It's unfortunate Maro is injured but he has been rehabbing well so we are hopeful he will be back earlier than maybe first predicted," he said.
"We have got great depth in the squad so Joe Launchbury and Courtney Lawes will fill his shoes very well."
Props Dan Cole, who has not played for England for 11 months, and Ben Moon, who made his debut last November, are also on the bench as Jones looks to combat an enormous French pack.
Winger Joe Cokanasiga and flanker Brad Shields were the men trimmed from Jones's provisional squad.
Ashton, who will start on the right wing with Jonny May on the left, has scored 20 tries in his 43 games though has not managed one in his five games against France.
"We have gone for Chris Ashton on the wing - we think he might sneak us a try early in the game," Jones said.
"Jack Nowell was brilliant against Ireland and he'll play a significant role for us off the bench."
France got off to a rocky start last week, starting well but blowing a 16-0 half-time lead to lose 24-19 at home to Wales after a series of blunders.
They also have a dire recent record at Twickenham, having won once there in the Six Nations this century.
They have made six changes, including the return of giant centre Mathieu Bastareaud.
England: Elliot Daly, Chris Ashton, Henry Slade, Manu Tuilagi, Jonny May, Owen Farrell (capt), Ben Youngs, Billy Vunipola, Tom Curry, Mark Wilson, George Kruis, Courtney Lawes, Kyle Sinckler, Jamie George, Mako Vunipola. Res: Luke Cowan-Dickie, Ben Moon, Dan Cole, Joe Launchbury, Nathan Hughes, Dan Robson, George Ford, Jack Nowell.