An early goal from Neymar and a late second from Lucas Paqueta gave Brazil a 2-0 win against Paraguay in a World Cup qualifier in Asuncion, sending them to a sixth straight victory in South America's preliminaries.
Neymar controlled an awkward cross from Gabriel Jesus and side-footed home from out to give Brazil the lead with three minutes gone.
Paqueta sealed all three points in the fourth minute of stoppage time with a splendid left-footed shot into the bottom corner.
Brazil have a maximum 18 points after six games of the South American qualifying group for Qatar 2022.
Miguel Borja has scored in the last seconds of added time to secure a 2-2 draw for Colombia against Argentina in one of the best matches yet in South American qualifying for the 2022 World Cup.
The match at the Metropolitano stadium in Barranquilla was attended by 10,000 fans despite the region's alarming COVID-19 figures.
Lionel Messi's Argentina line-up scored twice in the first eight minutes.
Cristian Romero headed past David Ospina in the third minute and Leandro Paredes doubled the lead after dribbling through the middle of Colombia's defence and sliding a shot into the back of the net.
But Colombia lifted in the second half, as Argentina were either failing at the finishing or being stopped by Ospina.
Argentina's Nicolas Otamendi conceded a penalty and Luis Muriel scored from the spot at the 51st.
It appeared Argentina would take another step closer to the World Cup with an away win but Borja's header triggered wild celebrations for the hosts.
The top four teams in South American qualifiers will advance automatically to Qatar 2022.
The fifth-place team will go into an inter-continental playoff.
Earlier on Tuesday, Peru won their first match of the qualifiers, 2-1 over Ecuador, thanks to two assists from Gianluca Lapadula.
In the 61st he found Christian Cueva in the box and in the 88th he assisted Luis Advincula, who shot from close range.
Gonzalo Plata scored Ecuador's only goal in added time.
Fourth-placed Uruguay drew 0-0 at second bottom Venezuela in a match with few exciting moments.
In the last of the day's five games, Chile drew 1-1 with Bolivia in Santiago.
The home side went 1-0 up thanks to a 69th minute goal from Erick Pulgar but Marcelo Martins scored from the penalty spot, his third goal in two games, to equalise with eight minutes remaining.
The result leaves Chile seventh in the table, one spot above Bolivia. Venezuela and Peru are joint bottom.
The next round of matches in South American World Cup qualifiers will be played in September and October.