Phil McNulty, BBC Sport
Spurs came close to earning a replay at Etihad Stadium but would have been somewhat fortunate to do so after being dominated for much of the tense tie.
Ange Postecoglou’s side were finally breached two minutes from time when Nathan Ake scored from close range, after Spurs keeper Guglielmo Vicario failed to claim Kevin De Bruyne’s corner under pressure from Ruben Dias.
It is a bitter blow to Spurs and Postecoglou, as they would've relished an FA Cup run, but there is still plenty to fight for in a season that has offered such promise and optimism.
Spurs are currently fifth in the Premier League, well in the fight for a place in the top four and next season’s Champions League. Postecoglou will ensure they re-focus after this disappointment.
One man Spurs cannot replace is captain Heung-Min Son, who is currently away with South Korea at the Asian Cup. He was sorely missed as an attacking outlet against City and his return cannot come soon enough.
Spurs will be wounded by this FA Cup loss – but they still have much to play for.