Drew Brees v Tom Brady, and the battle for NFL supremacy of the NFC South, was a one-sided affair as the New Orleans Saints thumped the Tampa Bay Bucaneers 38-3.
The Saints (6-2) won their fifth-straight game to move clear at the top of their division, intercepting Brady three times in Sunday's game to complete a season sweep of the Bucaneers (6-3).
Brees threw for four touchdowns, to take his career tally to 564 and three clear of Brady at the head of the all-time list.
"Obviously, tonight was a great night," Brees said.
"All the way around, in all three phases, it was pretty exceptional."
It is the first time in Brady's career that he has lost twice to the same team in one season.
"We didn't play well in any phase of the game," Brady said.
Ben Roethlisberger threw all three of his touchdown passes after shrugging off a knee injury to lead the Pittsburgh Steelers to a 24-19 defeat of the Dallas Cowboys.
Pittsburgh are 8-0 for the first time in the storied franchise's history despite an upset bid from the Cowboys (2-7), who were the biggest underdogs they've been at home in at least 31 years.
Josh Allen won his quarterback duel with Russell Wilson as the Buffalo Bills beat the Seattle Seahawks 44-34 to move to 7-2 for the first time since 1993.
Playing the day after the death of his grandmother, Allen threw for 415 yards and three touchdowns with the Seahawks 6-2 on the season.
The Kansas City Chiefs overturned an early 14-3 deficit to beat the Carolina Panthers 33-31 and move to 8-1 in defence of their Super Bowl crown.
The Baltimore Ravens moved to 6-2 with a 24-10 win over the Indianapolis Colts while the Minnesota Vikings recorded a 34-20 win over NFC North rivals the Detroit Lions.
The Tennessee Titans defeated the Chicago Bears 24-17, the New York Giants beat Washington 23-20 and the Miami Dolphins accounted for the Arizona Cardinals 34-31.
The Houston Texans edged the Jacksonville Jaguars 27-25 while Matt Ryan threw three touchdown passes in the Atlanta Falcons' 34-27 win over the Denver Broncos.
The Las Vegas Raiders were 31-26 victors after a replay showed a seemingly game-winning touchdown from the Los Angeles Chargers' Donald Parham Jr on the final play was fumbled.