Collingwood have finally lost patience with forward Chris Dawes, dropping him for Saturday's clash against Essendon, while Hawthorn and Geelong have both welcomed back key players.
Dawes has endured a tough season with 14 goals from his 20 games, including zero in his past three, and coach Nathan Buckley has decided to omit the 24-year-old on the eve of the finals.
Jackson Paine is his replacement in the forward line, while the Magpies have also regained the services of captain Nick Maxwell, ruckman Darren Jolly and Andrew Krakouer for his first game of the season following a knee reconstruction.
Jamie Elliott is the other inclusion with Cameron Wood, Ben Sinclair, Paul Seedsman and Jarryd Blair (groin) joining Dawes out of the side.
The Bombers have lost Heath Hocking (knee), Nathan Lovett-Murray (hamstring), Alwyn Davey (hamstring) and Scott Gumbleton (soreness) to injury, while Alex Browne has been omitted.
Into the side come ruckman David Hille, David Myers, Ben Howlett, Cory Dell'Olio and debutant Jackson Merrett.
The Hawks enter their clash against West Coast on Friday night with arguably their best side of the season with excitement machine Cyril Rioli returning after two weeks out with a shoulder injury.
Xavier Ellis is the unlucky player to make way, while ruckman Max Bailey remains on the outer.
The Eagles lost Matthew Rosa (collarbone) and Eric Mackenzie (hamstring) to injury with Mitch Brown and Jacob Brennan both returning, although there is still no room for Quinten Lynch.
Geelong have welcomed back captain Joel Selwood, Matthew Scarlett, Taylor Hunt and Nathan Vardy, who is playing his first game of the season following persistent hip problems, for their clash against Sydney at Simonds Stadium.
The Swans have also regained a key player with veteran Jude Bolton back in the side, along with Tommy Walsh, but they have lost Sam Reid to a glute injury, while Mitch Morton has been dropped.
Adelaide have resisted the urge to rest players for their clash against Gold Coast at AAMI Stadium, although Bernie Vince will miss with a knee injury.
Key midfielder Rory Sloane is back in, along with Matthew Jaensch with Luke Brown omitted.
The Suns have made just the one change with Jeremy Taylor replacing Josh Toy.
North Melbourne have also decided against resting players with coach Brad Scott naming an unchanged side for their clash against GWS at Skoda Stadium.
The Giants have made a host of changes with experienced players Tom Scully, Rhys Palmer, Chad Cornes, Dean Brogan and NRL convert Israel Folau among seven inclusions.
Youngsters Sam Darley (foot) and Nathan Wilson (cheekbone) are out injured, while Adam Tomlinson, Tomas Bugg, Rhys Cooyou, Anthony Miles, Andrew Phillips and Nathan Wilson have all been left out.
Fremantle have named captain Matthew Pavlich for their clash against Melbourne at Patersons Stadium, although doubts still surround the fitness of the Coleman Medal leader.
Ruckman Jon Griffin has also been recalled, along with debutant Thomas Sheridan with Kepler Bradley (concussion), Matthew de Boer (ankle) and Zac Clarke all out of the side.
The Demons have made just three changes with Mark Jamar, Jack Fitzpatrick and Josh Tynan replacing Jake Spencer, James Strauss and the retired Brad Green.
Brett Ratten has included potential debutants Pat McCarthy and Luke Mitchell for their clash against St Kilda at Etihad Stadium on Sunday in what will be the Carlton's coach last game in charge.
Mitch Robinson is also back in the squad with Levi Casboult (kidney) and Andrew McInnes (knee) the only confirmed outs at this stage.
The Saints have lost Sam Gilbert to a shoulder injury with senior players Jason Blake, Jason Gram, Justin Koschitzke and David Armitage all set to return.
Richmond have added Tom Derickz, Brandon Ellis, Todd Elton and Addam Maric to their squad to play Port Adelaide at the MCG on Sunday with Matthew White (hamstring) the only confirmed out.
The Power have lost Matthew Lobbe to a hamstring injury with Hamish Hartlett, Jarrad Redden, Daniel Stewart and Simon Phillips all included in the extended squad.
Finally, Brisbane are set to hand a debut to Sam Docherty, while Amon Buchanan looks likely to get a farewell game against the Western Bulldogs in the final match of the season at the Gabba.
The Dogs will be without Daniel Giansiracusa (knee), but have regained the services of Brian Lake with Matthew Panos also a chance to debut.