Geelong have been dealt a big blow ahead of Friday night's clash with West Coast, with three key players ruled out through injury.
Midfielder James Kelly has a groin complaint and won't be risked for the crucial Round 20 match, while Josh Hunt (quad) and Billie Smedts (calf) are also out.
Coming into the Geelong side are a trio of youngsters, with Jonathan Simpkin, Cameron Guthrie and Jordan Murdoch all named.
West Coast have brought back important midfielder Andrew Embley for his first game since Round 2, alongside Darren Glass and Jacob Brennan.
Mitch Brown has been omitted, while Sam Butler (calf) and Brad Sheppard (ankle) are out injured.
Collingwood have called on a trio of veterans to play against the Swans in Sydney on Saturday night, with Alan Didak, Martin Clarke and Chris Tarrant all named by Nathan Buckley.
Dane Swan will serve the first week of his two-game club-imposed suspension, while Tyson Goldsack (ankle) and Tom Young are out.
The Swans lose Jude Bolton to a knee injury, with former Bulldog Andrejs Everitt named as his replacement.
There was no return for Lance Franklin as Hawthorn coach Alastair Clarkson opted to give his star forward another week on the sidelines.
Clarkson included Max Bailey, Xavier Ellis, Stephen Gilham and Taylor Duryea in his squad of 25 to face Port Adelaide, with Liam Shiels (suspended) the only out at this stage.
Port named first-gamer Nathan Blee in their side and welcome back Troy Chaplin, David Rodan, Jarrad Redden and Darren Pfeiffer.
Alipate Carlile (back) and Thomas Jonas (calf) drop out.
Essendon have been boosted by the return of Dustin Fletcher, Angus Monfries and Stewart Crameri for their vital match with North Melbourne.
The trio head a list of inclusions for James Hird's side, with Jason Winderlich (hamstring), Ben Howlett (hamstring) and Tayte Pears all missing out.
North have added Aaron Edwards, Leigh Adams and Levi Greenwood to their squad.
There was mixed news for Adelaide ahead of their game with Fremantle, after they lost Jason Porplyzia to a shoulder injury, but regained key forward Kurt Tippett.
The Dockers named Alex Silvagni as the replacement for the suspended Luke McPharlin and also included Nick Suban, while omitting Dylan Roberton.
Carlton welcome back Mitch Robinson and Andrew Walker for their clash with the Brisbane Lions, while Matthew Watson and Rhys O'Keefe have also been included.
Making way are Andrew Collins, Aaron Joseph, Marcus Davies and the injured Michael Jamison.
The Lions lose Josh Drummond to soreness, but have added Matt Maguire, Claye Beams, Ryan Lester and Rohan Bewick.
St Kilda made just the one change for their match with Melbourne, with Beau Wilkes in for Dean Polo.
The Demons lose Cale Morton to a shoulder injury and dropped the unlucky Jordan Gysberts and have named Neville Jetta and Jordan McKenzie as their replacements.
There were a host of changes to both sides ahead of the match between the two newest clubs in the AFL.
Gold Coast lose Michael Rischitelli (knee), Zac Smith (ankle) and Karmichael Hunt (shoulder), Luke Russell (shoulder), Sam Day (foot) and Dion Prestia (hamstring), with Kyal Horsley and Danny Stanley among the six inclusions.
Greater Western Sydney also made six changes, with Callan Ward (groin), Jonathon Patton (shoulder), Tony Greene (groin), Taylor Adams (back), Sam Frost (hip) and Dean Brogan all dropping out.
Former rugby league star Israel Folau will play though, while Xavier College product Tim Golds will debut.
And finally, two players may make their debuts for the Western Bulldogs against Richmond after Lin Jong and Fletcher Roberts were both named in their squad of 25.
Richmond added Matt Dea, Tom Derickx and Brett O'Hanlon to their squad, with teams for matches on Sunday to be finalised on Friday evening.