Jamie Elliot and Marley Williams will make their Collingwood debuts against the Crows on Saturday, while Geelong welcome back Matthew Scarlett.
With Premiership pair Dane Swan (hamstring) and Ben Reid (quad) expected to miss two weeks, Nathan Buckley has called upon Murray Bushrangers recruit Elliot and 19-year-old midfielder Williams for Saturday night's match against Adelaide.
For the in-form Crows, Richard Douglas returns to the squad for the first time since Round 2, replacing Tom Lynch.
Scarlett, who missed Geelong's loss to Collingwood last week with an ankle injury, returns to take on the Western Bulldogs on Friday night.
Jonathan Simpkin, a 24-year-old small forward promoted from the Cats' rookie list on Thursday, will make his debut against the Dogs, while James Kelly (calf) and Billie Smedts miss out.
The Dogs welcome back Adam Cooney, Jordan Roughead and Patrick Veszpremi and also hand a debut to Daniel Pearce, pick No. 49 in last year's national draft.
Dylan Addison is out through suspension, while Jarrad Grant, Liam Jones and Clay Smith have been omitted.
Hawthorn remain unchanged for Saturday's match against Richmond at the MCG but the Tigers have made two changes.
Ben Griffiths will play his first match of the 2012 season and just the 10th of his career, coming in for Dylan Grimes (hamstring), while Tyrone Vickery is recalled at the expense of Brad Miller.
Gold Coast Suns, who are still searching for their first win at Metricon Stadium, have decided to rest youngster Luke Russell for the game against Port Adelaide, with Alik Magin taking his place.
The Power make one change as forward John Butcher (hip) drops out for Daniel Stewart.
St Kilda have made two changes to their side for the showdown with the unchanged Sydney Swans on Saturday afternoon.
Having undergone a knee reconstruction last year, James Gwilt will play his first game of the 2012 season in place of Beau Wilkes, while Arryn Sippos steps in for the injured Rhys Stanley (hamstring).
Tomas Bugg, Curtly Hampton, Dylan Shiel, Devon Smith, Adam Kennedy and James McDonald have all been recalled by Kevin Sheedy for Saturday night's encounter against Essendon.
Nathan Wilson, Rhys Palmer, William Hoskin-Elliot, Matthew Buntine, Adam Tomlinson and Toby Greene (suspension) drop out.
For the Bombers, Dustin Fletcher has succumbed to a groin injury and misses out along with Dyson Heppell (knee) and Leroy Jetta (suspension).
Experienced midfielder Mark McVeigh, Tayte Pears and Travis Coyler will all play against the league's new boys.
Winless Melbourne have wielded the axe for their bout against Carlton.
Aaron Davey, Colin Sylvia and Cale Morton have paid the price for underperforming, as Lynden Dunn and Luke Tapscott head the list of inclusions.
Carlton have named an extended squad with Brock McLean included to face his former team.
Nick Duigan (calf) joins Marc Murphy (shoulder), Jordan Russell and Bret Thornton on the sidelines.
Brad McKenzie misses out for the Kangaroos but Aaron Edwards, Cruize Garlett, Samuel Wright and Aaron Black have been added to an extended squad, as Lindsay Thomas gets set to play his 100th game against the Brisbane Lions.
Elliot Yeo is set to play his first AFL game after Michael Voss included the former East Fremantle product in Brisbane's extended side.
Matthew Priddis is back for Sunday's Western Derby, with Ashton Hams and Scott Lycett also named for 2006 Premiers West Coast.
Garrick Ibbotson and Dylan Robertson have been dropped by Fremantle.